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ID 17394
Eprint ID
17394
FullText URL
Thumnail 90_851.pdf 579 KB
Title Alternative
CSF monoamine metabolites and cyclic nucleotides in chronic schizophrenic patients with tardive dyskinesia or drug-induced tremor
Author
Nagao, Takuo
Abstract
Lumbar CSF HVA, MHPG, 5HIAA, cAMP and cGMP were measured in 12 chronic schizophrenics with tardive dyskinesia (TD) before and 3 weeks after sodium valproate (VPA) or cyproheptadine treatment. The amount of medication was kept constant throughout the study. Three of the 7 patients treated with VPA and 1 of the 5 with cyproheptadine showed improvement. HVA levels significantly decreased and cAMP and cGMP levels significantly increased. MHPG levels increased significantly during the treatment with VPA but declined during cyproheptadine treatment. There were no significant correlations between the degree of improvement in TD and the changes of amine metabolites or cyclic nucleotides. None of the pre-treatment values for CSF amine metabolites or cyclic nucleotides were different from those of 15 chronic schizophrenics without TD as controls. Decrease in HVA and increase in cGMP during the treatment might indicate the normalization of dopaminergic-cholinergic imbalance in the brain. Furthermore, amine metabolites and cyclic nucleotides were measured in 5 chronic schizophrenics with parkinsonian tremor. Low HVA and 5HIAA levels and high cAMP levels were observed in tremor group. However, only 5HIAA levels in tremor group were significantly lower than those in age-matched control group. It is suggested that neuroleptic-induced tremor may be attributed to serotonergic dysfunction in the brain.
Published Date
1978-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
851
End Page
861
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/7-8/90_7-8_851/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma