このエントリーをはてなブックマークに追加
ID 17332
Eprint ID
17332
FullText URL
Thumnail 87_147.pdf 4.49 MB
Title Alternative
Studies on the leukemogenesis by injection of a carcinogenic chemical substance in newborn mice
Author
Nagamori, Teiichiro
Abstract
In order to study the leukemogenesis by a carcinogen chemical substance in newborn mice, various doses of benzpyrene (BP) were administered by a single subcutaneous injection into newborn RF mice, and hematological and histlogical analyses were made periodically afer the injection. Leukemia was induced in a high percentage of treated mice. They are all lymphocytic leukemia of thymic type, except one case of non-thymic type. A parallel correlation was observed between the doses of the carcinogen administered and the incidence of leukemia. The leukemic change occurred first in the cortical area of the thymus 1.5 months after BP injection, followed by the leukemic infiltration in various other organs and leukemic death in three months. Fibrosarcoma was also observed in the treated mice. Leukemia and fibrosarcoma were both transplantable with cell. Numerous C-type virus particles with budding were demonstrated by electron microscopy in the lymph nodes of BP-induced leukemic mice. From these findings, the author concludes that 1) the newborn mice are more susceptible than adult mice to the chemical carcinogen BP, 2) the thymus is the target organ and it plays an important role in the development of leukemia by BP, and 3) BP may induce leukemia by activating the provirus.
Published Date
1975-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume87
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
147
End Page
171
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/87/1-2/87_1-2_147/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma