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ID 17278
Eprint ID
17278
FullText URL
Thumnail 90_457.pdf 195 KB
Title Alternative
The levels of human erythrocyte superoxide dismutase activity classified by age and in vitro inhibition by some polluting agents Part 3 In vitro inhibition of cytoplasmic superoxide dismutase by some polluting agents (cyanide ions, nitriles, dimethyldithiocarbamate, paraquat and Gramoxon)
Author
Ueda, Kazuko
Abstract
In vitro inhibition of cytoplasmic SOD by cyanide ions, nitriles, dimethyldithiocarbamate, paraquat and Gramoxon was determined. In this experiment NBT reduction in aerobic xanthine oxidase system was used. Inhibition by polluting agents against crude extract of SOD of human erythrocytes and purified SOD from bovine blood. The following results were obtained. 1, Potassium cyanide inhibits SOD reaction, giving 50 percent inhibition at 0.036mM in crude extract of human blood and 0.043mM in purified bovine blood SOD. 2, No inhibition was observed by nitriles up to 20mM both in crude extract and purified SOD. 3, Sodium thiocyanate gives no inhibition up to 40mM both in crude extract and purified SOD. 4, Dimethyldithiocarbamate inhibits SOD reaction giving 50 percent inhibition at 0.66mM in crude extract and 0.96mM in purified SOD. 5, Paraquat inhibits SOD reaction giving 50 percent inhibition at 0.06mM in crude extract and 1.09mM in purified SOD. And Gramoxon containing 24 percent paraquat and certain surfactants gives 50 percent inhibition as low as 0.0054mM in crude extract and 0.0084 in purified SOD.
Published Date
1978-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
457
End Page
460
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/3-4/90_3-4_457/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma