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ID 17217
Eprint ID
17217
FullText URL
Thumnail 89_1203.pdf 756 KB
Title Alternative
Studies on platelet functions in myeloproliferative disorders Part 2. Studies on adenine nucleotides in platelet in myeloproliferative disorders
Author
Nozaki, Hiroyuki
Abstract
Abnormalities of platelet-function, particularly decrease of platelet aggregation, in myeloproliferative disorders have been already reported in Part 1 of this study. In this paper author studied a relationship between these abnormalities and Adenine Nucleotides (AN) in platelets. Materials were 26 cases of chronic myelocytic leukemia and 4 cases of polycythemia vera. AN in platelets (ADP, ATP) and released-AN (ADP, ATP) from platelets were assayed by Luciferin-Luciferase method. As results followings were obtained. In these myeloproliferative disorders, not only contents of ADP and ATP in platelets but also released-ADP and ATP have been significantly decreased. Furthermore, these cases have been classified into two groups: (i) cases, which showed decreased platelet aggregation and decrease of released-ADP and ATP due to decrease of contents of ADP and ATP in platelets. (ii) cases, which showed decreased platelet aggregation and decrease of released-ADP and ATP inspite of normal ADP and ATP contents in platelets. These results were thought to suggest that hemostatic abnormalities in myeloproliferative disorders might be classified into two categories, namely "Storage pool disease" and "Aspirin like release defect".
Published Date
1977-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1203
End Page
1220
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/9-10/89_9-10_1203/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma