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ID 17197
Eprint ID
17197
FullText URL
Thumnail 90_59.pdf 1.75 MB
Title Alternative
Effect of X-irradiation in rats bearing Walker-256-carcinosarcoma and normal rats -Changes in serum proteins-
Author
Ehara, Kazuhiko
Abstract
Serum protein fractions and total proteins were studied with bloods obtained form the rats exposed each to the partial-, whole-bodies and the transplanted tumors (Walker-256-carcinosarcoma transplanted in the right hind leg). The following results were obtained. 1. The electrophoretic variation induced in the sera of tumor-bearing rats (Group Ⅱ), and the content of total proteins decreased. Early irradiation to the tumor part of rats less induced the variations of the electrophoretic pattern and the decrease of the amount of serum total proteins. When the distant metastasis appeared during irradiation treatment, the electrophoretic patterns and content of total proteins changed proportionally to the variation in sera of Group Ⅱ. On the other hand, the γ-globulin fraction increased in the long-term survival rat. 2. The separation of the rat serum β-globulin into two peaks of β(1)-and β(2)-globulin was shown only in Group Ⅳ (late irradiation to the right hind leg). This finding supposed that some factors involve in the sera of rats with transplanted primary tumor grown up to a fixed size and guessed the appearance of the distant metastasis during X-irradiation. 3. The percentages of the albumin and γ-globulin decreased slightly and those of the α(1)-, α(2)and β-globulin increased slightly in the rats with 300 rad partial-body (the right hind leg) X irradiation daily for 20 days. 4. The remarkable decrease of the albumin and γ-globulin, the increase of the α(1) and β-globulin, the marked increase of the α(2)-globulin and the decrease of serum total proteins were demonstrated for the sera of rats with 1,000 rad whole-body X-irradiation at a time. These phenomena seem to be related to the destructive and reticuloendothelial injury by the exposure.
Published Date
1978-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
59
End Page
68
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/1-2/90_1-2_47/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma