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ID 17195
Eprint ID
17195
FullText URL
Thumnail 90_47.pdf 1.91 MB
Title Alternative
Influence of differential hypothermia on Vx2 tumor transplanted in rabbit Part 2. Tissue levels of anti-tumor agent during differential hypothermia
Author
Yamada, Osamu
Abstract
The effect of differential hypothermia (D.H.) combined with anti-tumor agent, 5-fluorouracil (5-FU), was described in the previous report (Part 1). In this study, the tissue levels of 5-FU in the tumor and other organs during D.H. treatment were examined by bioassay method. At first, using Vx2 tumors transplanted into the bilateral ears of the rabbits, D.H. treatment was performed with the same procedures as Part 1. The tissue level of 5-FU in the tumors, detected 45 minutes after administration, was the highest in the D.H.-treated tumors (22.1μg/g), as compared with contra-lateral, hypothermic tumors (11.4μg/g) and non-treated, normothermic tumors (6.8μg/g). The tissue level of 5-FU in other organs such as lung, kidney, skin, liver and brain was low in both hypothermic and normothermic conditions. But blood level of 5-FU was kept relatively high during generalized hypothermia (1hr.; 150μg/ml, 2hrs.; 10.4μg/ml), as compared with normothermia (1hr.; 5.5μg/ml, 2hrs.; 0.5μg/ml). The author further investigated that the tissue level of 5-FU in the brain tumors (Vx2 tumors transplanted into the brain of rabbit) was affected with D.H. treatment. In this experiment, the tumors were kept normothermic by irradiation of 2.45 GHz microwave under general body coiling. The D.H. treated brain tumors revealed higher level of 5-FU (19.6μg/g) than the nontreated brain tumors (6.4μg/g).
Published Date
1978-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume90
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
47
End Page
57
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/90/1-2/90_1-2_47/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma