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ID 17173
Eprint ID
17173
FullText URL
89_883.pdf 1.3 MB
Title Alternative
Co-existence of inhibitory and stimulatory factors on cell proliferation in a same rat liver supernatant and their regenerating changes
Author
Fujii, Toshitake
Abstract
Responding mechanism of regenerating hepatocytes induced by partial hepatectomy was studied. 1) Fibroblast inhibitory and stimulatory factors on fibroblast proliferation co-exist in the same rat liver supernatant, and they were simply isolated each other by ethanol fractionation. 2) These factors have protein components and lose the biological activities by heat-treatment, and they show the competitive activity each other, respectively. 3) In regenerating liver, stimulatory factor(s) was not remarkably changed, but inhibitory one almost lost the inhibitory activity. These phenomena are very rational and suitable for hepatocyte regeneration. 4) The inhibitory activity was separatedly eluted by DEAE-cellulose chromatography of inactive regenerating liver fraction, and new peak that did not exist in normal inhibitory fraction was detected in polyacrylamid gel electrophoresis of regenerating liver same fraction. 5) These phenomena suggest that a possible new anti-inhibitory factor(s) would be formed by partial hepatectomy.
Published Date
1977-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
883
End Page
894
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/7-8/89_7-8_883/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma