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ID 17135
Eprint ID
17135
FullText URL
Thumnail 89_659.pdf 1.05 MB
Title Alternative
Soluble factors of sensitized lymphoid cells that appear due to the difference in H-2 histocompatibility antigens Part 2. Study on the soluble factors by indirect macrophage migration inhibition test
Author
Takeuchi, Yoshiro
Abstract
For the in vitro studying allograft immunity of mice the soluble factors of sensitized lymphoid cells were investigated by indirect macrophage migration inhibition test. As a result it has been shown that the sensitized lymphoid cells obtained from A (H-2(a)) mouse previously sensitized by a skin graft from C3H (H-2(k)) mouse elaborate macrophage migration inhibition factor (MIF) over a long period of time though migration inhibitory activity is not so strong. The sensitized lymphoid cells obtained from C3H mouse previously sensitized by a skin graft from A mouse show a strong migration inhibitory activity but the period of MIF production is short. In either instance MIF becomes measurable 5 days after skin grafting, and it can no longer be measured after the time when all the skin graft has become necrotic. In other words, the extent of the migration inhibition activity seems to reflect the degree of difference in the H-2 histocompatibility antigens, and the time-lapse changes in MIF would serve as a useful parameter of allograft rejection.
Published Date
1977-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
659
End Page
665
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/5-6/89_5-6_659/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma