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ID 17119
Eprint ID
17119
FullText URL
Thumnail 89_565.pdf 220 KB
Title Alternative
Influence of phenobarbital and bucolome on biliary bilirubin
Author
Kondo, Tadasuke
Nakamura, Norio
Yonei, Jiro
Abstract
Biliary bilirubin conjugates were investigated in heterozygote Gunn rat after loading of phenobarbital or bucolome for 4 days. 50mg of phenobarbital or 200mg of bucolome per Kg of body weight was given intramusculary once a day. The bile collection by bile duct canulation was started 24 hours after the final drug loading and continued for 22 hours. The following results were obtained: 1) Bile volume increased significantly in both groups compared with the control group (no treatment group). The amount of excreted bilirubin increased significantly in the phenobarbital loading group than the control group, but not in the bucolome loading group. 2) A significantly increased amount of biliary bilirubin sulfate was observed in the Phenobarbital loading group compared with the control group, but not in the bucolome loading group. 3) The amount of excreted biliary bilirubin glucuronide increased significantly in the phenobarbital loading group compared with the control group, but not in the bucolome loading group.
Published Date
1977-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume89
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
565
End Page
569
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/89/5-6/89_5-6_565/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma