このエントリーをはてなブックマークに追加
ID 17060
Eprint ID
17060
FullText URL
Thumnail 92_587.pdf 406 KB
Title Alternative
Immunological studies on lupus nephritis Part 2. Studies on glomerular deposition of C(1)q
Author
Tarumi, Yoshinao
Abstract
C(1)q, the first component of C(1), was isolated from normal human sera according to Thunild's method. Specific antibody to C(1)q was produced in rabbits. Fluorescein isothiocyanate (FITC) was labelled on the antibody. Renal tissues from 35 patients with systemic lupus erythematosus (SLE) were stained with FITC labelled antibody to C(1)q as well as C(3), IgG, IgM and IgA. The following results were obtained. 1. Glomerular deposition of C(1)q was frequently seen in patients who had massive deposition of immunoglobulins and C(3) along the glomerular basement membrane. The distribution of C(1)q is similar to that of immunoglobulins and C(3). 2. Positive C(1)q deposition on glomeruli was associated with low levels of serum C(1)q and the presence of complement fixing antibody to native DNA. 3. Serial renal biopsy of 15 patients with SLE showed that a marked decrease of C(1)q deposition was observed after steroid therapy. These results indicate that glomerular deposition of C(1)q is of importance to evaluate the clinical and immunopathological activity of lupus nephritis.
Keywords
ループス腎炎
C(1)q
CF-n-DNA 抗体
Cg
immune complex
Published Date
1980-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume92
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
587
End Page
595
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/92/5-6/92_5-6_587/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma