このエントリーをはてなブックマークに追加
ID 17026
Eprint ID
17026
FullText URL
Thumnail 91_1507.pdf 3.45 MB
Title Alternative
An electroencephalographic study on Creutzfeldt-Jakob disease- Report of two autopsy cases and literature review
Author
Yoshinaga, Junji
Abstract
This report concerns 2 autopsy cases of Creutzfeldt-Jakob disease (CJD) in which the relationship between changes in serial electroencephalograms and the course of the disease is analysed. The importance of timing when periodic synchronous discharge (PSD) occurs was indicated. i.e., the appearance of PSD paralleled clinical manifestations of the apallic syndrome and was most distinct when the disease was at its worst. We reviewed the EEG findings in autopsy cases of CJD reported in Japan. Fifteen cases of typical PSD were found and these were examined clinico-pathologically. The findings were: 1. PSD was recorded within three months of the onset of the disease in two thirds of the 15 cases. 2. In 13 cases the clinical manifestations when PSD occurred were those of apallic syndrome or of similar conditions. 3. Following characteristics were found in the distribution of pathological changes in the brain; (a) The presence of extensive changes in the cerebral cortex was the only finding common to all cases. (b) The cerebral changes mainly occurred in the corpus striatum of the basal ganglia and in the medical nuclei of the thalamus. (c) Disturbances were least in the brain-stem below the level of the midbrain. (d) No definite tendency was apparent in the changes of the cerebral white matter and cerebellum. In conclusion, the mechanism of PSD may be accounted for by disturbances of the cortico-thalamic circuit. This circuit is said to be regulated by diffuse thalamic projection system. It is presumed that the extensive pathology in the cortex and medical nuclei of the thalamus plays an important role.
Keywords
Creutzfeldt-Jakob病
周期性同期性放電(PSD)
Published Date
1979-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1507
End Page
1525
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/11-12/91_11-12_1507/_article/-char/ja//jnlabstract_ja.php?cdjournal=joma1947&cdvol=91&noissue=11-12&startpage=1507
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma