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ID 17011
Eprint ID
17011
FullText URL
Thumnail 91_1455.pdf 253 KB
Title Alternative
Experimental study of Polychlorinated naphthalene (PCN) intoxication 1. Effect of PCNs on oxidative phosphorylation of rat liver mitochondriain a test tube
Author
Ohguma, Katsuaki
Abstract
Effect of PCNs on normal isolated mitochondrial membrane was studied and the results obtained were as follows. 1) PCNs inhibited the state 3 respiration, and stimulated the state 4 respiration (namely uncoupling action). 2) The proportional relationship between a decrease in RCI and an increase in concentration of Halowax 1001 (PCN) was recognized, and a decrease tendency of ADP/O ratio was observed within the range of PCN concentration measured. 3) PCNs induced a K(+) release in mitochondria and the release effect was the strongest in Halowax 1031 (PCN). 4) Discussion was made that effects of PCNs on the mitochondrial membrane were seemed to be related to their complex characters which are the content of chlorine and their isomers.
Keywords
ポリ塩化ナフタリン
酸化的リン酸化
呼吸活性
K(+)遊出
Published Date
1979-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1455
End Page
1460
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/11-12/91_11-12_1455/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma