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ID 17009
Eprint ID
17009
FullText URL
Thumnail 92_289.pdf 2.56 MB
Title Alternative
Studies on hairy cell leukemia Part Ⅰ. Establishment of a hairy cell leukemia line and its characteristics
Author
Hikita, Takao
Abstract
A hairy cell leukemia (HCL) line, ZK-H, and a normal lymphoblastoid cell line, ZK-N, were established from the peripheral blood of a 69-year-old male patient. The ZK-H cells and the patient's original hairy cells shared the same surface properties; both possessed membrane-bound IgG with kappa light chains and villous surface structures. The ZK-N cells were devoid of villous surface structures and polyclonal in that they consisted of cells having different membrane-bound heavy and light chains. Both the ZK-H and ZK-N lines carried Epstein Barr virus (EBV)-determined nuclear antigen, but the patient's fresh leukemic cells lacked this antigen. The ZK-H line had a hyperdiploid chromosome constitution of 47 and trisomy No. 2, but the ZK-N line had a normal chromosome constitution. The presence of membrane-bound immunoglobulin and B-cell tropic EBV in the ZK-H line provides evidence of the B-cell nature of HCL in this patient.
Keywords
hairy cell leckemia
組織培養
Published Date
1980-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume92
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
289
End Page
299
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/92/3-4/92_3-4_289/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma