| ID | 17007 |
| Eprint ID | 17007
|
| FullText URL | |
| Title Alternative | Increased disappearance rate of 1-(2-tetrahydrofuryl)-5-fluorouracil in reduced glutathione- or vitamin E-treated rats and its unresponsiveness to these drugs in carbon tetrachloride-injured rats
|
| Author |
Hobara, Norio
Watanabe, Akiharu
Nagashima, Hideo
|
| Abstract | The pharmacokinetics of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT) were analysed by measuring its disappearance rate (K) from the circulating blood using a high-pressure liquid chromatographic technique. An increase in the disappearance rate of FT was observed by treatment with reduced glutathione (GSH)- or tocopheryl nicotinate-treated rats. The clearance rates of FT from the circulating blood in carbon tetrachloride (CCl(4))-injured rats were much smaller than those in untreated rats. The unresponsiveness of K values to treatment with GSH or tocopheryl nicotinate was seen in liver-injured rats.
|
| Keywords | 四塩化炭素肝障害
FT
ビタミンE
還元型グルタチオン
血中消失速度定数
|
| Published Date | 1980-02-28
|
| Publication Title |
岡山医学会雑誌
|
| Publication Title Alternative | Journal of Okayama Medical Association
|
| Volume | volume92
|
| Issue | issue1-2
|
| Publisher | 岡山医学会
|
| Publisher Alternative | Okayama Medical Association
|
| Start Page | 267
|
| End Page | 271
|
| ISSN | 0030-1558
|
| NCID | AN00032489
|
| Content Type |
Journal Article
|
| Official Url | https://www.jstage.jst.go.jp/article/joma1947/92/1-2/92_1-2_267/_article/-char/ja/
|
| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
|
| language |
Japanese
|
| Copyright Holders | 岡山医学会
|
| File Version | publisher
|
| Refereed |
True
|
| Eprints Journal Name | joma
|
