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ID 16923
Eprint ID
16923
FullText URL
Thumnail 91_749.pdf 1.63 MB
Title Alternative
Morphological studies on human blood basophils in immunological reactions Part II. Scanning electron microscope observation of morphological changes in basophils challenged in vitro with anti-human immunoglobulins
Author
Kobayashi, Makoto
Abstract
Morphological change of blood basophils were investigated in 3 healthy controls, 4 atopic and 4 intractable asthmatics by scanning electron microscopy after they had been exposed to anti-human IgE or anti-human IgG. Most of the basophils from healthy controls, atopic and intractable asthmatics challenged with physiological saline solution (P. S. S.) were sphericalshaped. Basophils from atopic asthmatics, or basophils from healthy controls and intractable asthmatics after passively sensitized with IgE rich serum, were pear-shaped or 'swollen' when challenged with anti-IgE. In such conditions some basophils showed surface structural changes such as hemispheric projections, pore formation or ruptured cell membrane. Basophils from intractable asthmatics tended to be pear-shaped or 'swollen' and also showed surface structural changes as mentioned above when anti-IgG was added. The results show that not only IgE but also IgG may participate in the pathogenesis of bronchial asthma, especially of intractable asthma.
Keywords
好塩基球
走査電顕
抗ヒト免疫グロプリン
アトピー型喘息
重症難治性喘息
Published Date
1979-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume91
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
749
End Page
761
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/91/5-6/91_5-6_749/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma