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ID 16727
Eprint ID
16727
FullText URL
93_977.pdf 459 KB
Title Alternative
Studies on the Alternative Pathway in Systemic Lupus Erythematosus Using Rabbit Red Blood Cells Part 1. Fundamental Studies
Author
Miyashima, Hiroto
Abstract
Methods of measuring the activity of the total alternative complement pathway, properdin and Factor B with rabbit red blood cells(RaRBC) were examined. The following results were obtained. 1) 0.03M EGTA-GVB permitted activation of the alternative complement pathway without activation of the classical complement pathway. 2) RaRBC were hemolysed by C4/C2 depleted serum as well as by normal serum. RaRBC were not hemolysed by inulin or zymosan treated serum. 3) The activity of the total alternative complement pathway was measured with 50 % hemolysis of RaRBC in EGTA-GVB, designated as ACH50. 4) The activity of properdin or Factor B was measured with RaRBC and normal fresh human serum deficient in properdin (RP) or deficient in Factor B (RB).
Keywords
全身性エリテマトーデス
補体
alternative pathway総溶血活性
propendin活性
Factor B活性
Published Date
1981-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
977
End Page
985
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/11-12/93_11-12_977/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma