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ID 16599
Eprint ID
16599
FullText URL
96_1105.pdf 872 KB
Title Alternative
Studies on human peripheral monocytes Part Ⅱ. Membrane receptor and phagocytic function
Author
Sato, Toshio
Abstract
The phagocytic function of monocytes was measured by complement-binding zymosan particles (ZC). The phagocytic indices of monocytes prepared by glass-adherence and by gradient centrifugation were closely correlated (r=0.95, p<0.01). The former method was easier than the latter in the identification of monocytes. The phagocytic index was significantly reduced in patients with bronchogenic carcinoma (mean=53.2±20.2, p<0.01), malignant lymphoma (mean=52.9±20.6, p<0.01), and sarcoidosis (mean=51.1±20.2, p<0.01) compared with controls (mean=76.0±14.5). In contrast, there was no significant difference between controls and patients with pulmonary tuberculosis (mean=77.0±14.2). In bronchogenic carcinoma patients, a low phagocytic index was observed in all clinical stages. However, there was no significant correlation among phagocytic index, histological type and stage of disease. The C3 and Fc receptors of monocytes were also determined by rosette formation with ZC and IgG-treated ox erythrocytes (EA), respectively. In bronchogenic carcinoma, the percent of C3 receptor bearing monocytes was lower than that of controls, but the percent of Fc receptor bearing monocytes was in the normal range. However, the phagocytosis of EA was enhanced in comparison with controls. These data showed that monocyte phagocytic function was suppressed in patients with bronchogenic carcinoma. It was suggested that malignant tumors might affect monocyte function.
Keywords
monocyte
phagocytosis
receptor
lung cancer
Published Date
1984-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1105
End Page
1117
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1105/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma