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ID 16521
Eprint ID
16521
FullText URL
Thumnail 93_203.pdf 757 KB
Title Alternative
Studies on immunological aberration and its pathogenetic roles in patients with systemic lupus erythematosus. Part 2. Studies on suppressor T cell function
Author
Nakamura, Zenichi
Abstract
Peripheral mononuclear cells from patients with systemic lupus erythematosus(SLE), when incubated for 48hr with or without concanavalinA(ConA), were found to be capable of inhibiting the pokeweed mitogen(PWM)-induced polyclonal immunoglobulin(Ig) secretion of cells from normal individuals. Furthermore, anti-T cell antibody in sera from patients with SLE could not preferentially kill the precursor cells of ConA-induced suppressor cells. However, in SLE these suppressor cells did not significantly affect the Ig secretion of autologous B cells. These results suggest that defective suppressive activity in patients with SLE does not occur at the T cell level, but that it is most likely due too the defect of B cells in recognizing suppressive information from suppressor T cells, which is caused by in vivo polyclonal B cell activation.
Keywords
suppressor T cell function
PWM-induced Ig secretion
polyclonal B cell activation
systemic lupus erythematosus
Published Date
1981-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume93
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
203
End Page
217
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/93/3-4/93_3-4_203/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma