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ID 16496
Eprint ID
16496
FullText URL
Thumnail 96_767.pdf 11.6 MB
Title Alternative
Effect of heat-labile enterotoxin from enterotoxigenic Escherichia coli on the structure of rabbit intestinal epitherial cell and the brush border
Author
Nagata, Akihide
Abstract
Heat-labile enterotoxin produced by enterotoxigenic E. coli affected the structure of epitherial cell of rabbit intestine. The toxin bound to the microbilli of the cell and caused "puffing" of the microvillous membrane when it was examined under phasecontrast microscopy. The same change occured by the isolated brush border membrane if it was reacted with the enterotoxin in the presence of ATP. Electronmicroscopic observation disclosed that the bundle fibrous structure of the brush border was deformed to random structure and that some parts of the fibrous bundle detached from microvillous membrane. Since the enterotoxin bound to microvilli, it was suggested that cytoskelton including actin and myosin system of the cell could be affected through cAMP of which synthesis was activated at the microvilli membrane by the enterotoxin.
Keywords
毒素原性大腸菌
エンテロトキシン
小腸絨毛上皮細胞
刷子縁
サイトスケルトン
Published Date
1984-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
767
End Page
777
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/7-8/96_7-8_767/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma