ID | 16445 |
Eprint ID | 16445
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FullText URL | |
Title Alternative | A study of the pituitary prolactin reserve in normal children
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Author |
Araki, Kumiko
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Abstract | 下垂体prolactin(以下PRLと略す)は魚類からヒトにいたるまで,広くみとめられる系統発生学的に古いホルモンであり,その生理作用として魚類での電解質代謝,滲透圧調節,両生類での変態促進,爬虫類での成長促進,鳥類でのチーズ様嗉嚢乳の形成,哺乳類での乳腺発育などが知られている1).ヒトではPRLと成長ホルモンとの分離が困難であったが,1972年,Friesenら2)により初めてPRLが抽出純化され,その測定法としてradioimmunoassay法が確立された.以来ヒトにおけるPRLの作用機序に関する多数の研究が報告され, PRLには乳汁分泌作用の他に,性腺機能維持あるいは胎児肺の成熟促進作用3)などもあることが次第に解明されてきた.また,成人ではthyrotropin releasing hormone(以下TRHと略す)負荷によるPRLの分泌反応に関する多数の研究が報告され,性腺機能障害の診断のみならず,視床下部一下垂体系の障害部位の診断にも応用されるようになった(4)).一方,小児科学領域では,PRLの作用機序に関して,詳細な研究は,いまだ報告されておらず,PRLの成長あるいは性成熟などに及ぼす生理的意義についても不明の点が多い.本研究では,小児期におけるPRLの基礎値とTRH負荷による下垂体のPRL分泌予備能とを測定し,またこれと平行してluteinizing hormone releasing hormone(以下LH-RHと略す)の負荷による下垂体のluteinizing hormone(以下LHと略す)分泌予備能を測定し,小児の発育および思春期の性成熟に対するPRLの分泌動態について検討した.
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Abstract Alternative | In order to assess the change in the pituitary prolactin (PRL) reserve during development, serum prolactin response to TRH and serum LH response to LH-RH were studied in 247 normal children aged from 1 to 18years. The basal PRL level, of which the geometric mean (-1SD and +1SD) was 7.1 (4.6-11.0) ng/ml, was not affected by bone age or sex. The maximum increment in serum PRL above the baseline level (max.⊿PRL) correlated well both with the integrated secretion of PRL (p<0.001) and with the serum PRL releasing value per minute computed from the mathematical model of Okuno et al. (1977): C=α/β-α•Q(0)/V(e-αt-e-βt)+C(0e)-βt[α: rate constant for PRL release, β: rate
constant for PRL elimination, Q(0)/V: serum PRL releasing value per minute]. Hence, max. ⊿PRL can serve as a reliable index of the pituitary PRL reserve. The max. ⊿PRL increased with advancing age until early puberty in both sexes. Thereafter, however, the max. ⊿PRL decreased in doys, while it continued to increase in girls. In parallel with the increase in max. ⊿PRL, the pituitary LH reserve increased with advancing age until early puberty in boys and until late puberty in girls. In each of the individuals, studied, the rise in the LH reserve always preceded that in the PRL reserve. It seemed likely that in prepubertal children the pituitary PRL reserve was modulated by LH-RH, but aftre puberty by testosterone and estrogen as well.
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Keywords | prolactin 分泌予備能
TRH, LH-RH 負荷試験
性成熟
骨年令
luteinizing hormone
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Published Date | 1984-04-30
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Publication Title |
岡山医学会雑誌
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Publication Title Alternative | Journal of Okayama Medical Association
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Volume | volume96
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Issue | issue5-6
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Publisher | 岡山医学会
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Publisher Alternative | Okayama Medical Association
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Start Page | 601
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End Page | 614
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ISSN | 0030-1558
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NCID | AN00032489
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Content Type |
Journal Article
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Official Url | https://www.jstage.jst.go.jp/article/joma1947/96/5-6/96_5-6_601/_article/-char/ja/
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Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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language |
Japanese
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Copyright Holders | 岡山医学会
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File Version | publisher
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Refereed |
True
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Eprints Journal Name | joma
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