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ID 16444
Eprint ID
16444
FullText URL
Thumnail 95_1329.pdf 528 KB
Title Alternative
Studies on Reticuloendothelial Function in Patients with Systemic Lupus Erythematosus and Mice Part 2. Splenic Fc-Receptor Function (SFcF) in Patients with Systemic Lupus Erythematosus.
Author
Miyake, Hayashi
Abstract
The function of the reticuloendothelial system (RES) is important for deposition of circulating immune complexes (IC) in tissue. However, little is known about how IC located in tissues in patients with systemic lupus erythematosus (SLE). Splenic Fc-Receptor function (SFcF) was studied in 29 patients with SLE using IgG coated (51)Cr labelled autologous erythrocytes, and was compared with immunological abnormalities in sera and kidney. Impairment of SFcF was found in 21 of the patients (72.4%). There was a close inverse correlation between SFcF and CH50 (p<0.05). Patients with impaired SFcF tended to have a high level of circulating IC, but this was not statistically significant (p>0.05). A marked decrease in SFcF was found in patients with mesangial lupus nephritis and those with diffuse proliferative lupus nephritis. Patients with membranous lupus nephritis showed a mild SFcF abnormality. Decreased SFcF was reversible by steroid and/or plasma exchange (PE) therapy. Decreased SFcF could be improved after PE therapy alone. It was suggested that an abnormality in SFcF might force the progress of the diesase in patients with SLE.
Keywords
Reticuloendothelial system
Splenic Fc-receptor Function
Systemic Lupus Erythematosus
Published Date
1983-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1329
End Page
1340
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/11-12/95_11-12_1329/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma