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ID 16439
Eprint ID
16439
FullText URL
Thumnail 96_569.pdf 509 KB
Title Alternative
Studies on the biological toxicity of several brominated benzene pollutants of the environment Report 4. Biological fate of brominated benzenes in animals
Author
Ogino, Yasuo
Abstract
Movement of brominated benzenes in rats and mice was investigated. The concentration of o-dibromobenzene in several tissues and organs reached the highest value within 10 hours of a single oral administration and then decreased rapidly. The accumulation of o-dibromobenzene in tissues and organs was in the descending order of adipose tissue, liver (=pectoral muscle), kidney, brain and blood. A similar tendency was observed in mono-and tribromobenzene administered animals. The concentration of hexabromobenzene following continuous intraperitoneal administration reached the highest value 16.3 (liver) to 28.8 days (brain) after the administration. The biological half life of hexabromobenzene ranged from 2.0 (kidney) to 4.1 days (brain) in the first phase of excretion, and from 5.2 (kidney) to 7.3 days (adipose tissue) in the second phase of excretion. Accumulation of hepatic triglyceride due to administration of brominated benzenes occurred. A decrease in the percentage of arachidonic acid among total fatty acids was observed after the administration of brominated benzenes. It is suggested that accumulativeness of brominated benzenes becomes higher with the number of bromine atoms. Clonic toxicity induced by these compounds needs to be investigated in this connection.
Keywords
臭素化ベンゼン
臓器分布
排泄経過
Published Date
1984-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
569
End Page
578
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/5-6/96_5-6_569/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma