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ID 16420
Eprint ID
16420
FullText URL
Thumnail 95_1193.pdf 1.14 MB
Title Alternative
Studies on human peripheral monocyte-mediated cytotoxicity Part I. Monocyte-mediated cytostasis in malignant cells
Author
Yamashita, Jiro
Abstract
The monocyte-mediated cytostatic acitivity against human tumor cells was measured in healthy donors and patients with bronchogenic carcinoma, malignant lymphoma, sarcoidosis and pulmonary tuberculosis. The target cells employed were HeLa cells and squamous cell-type lung cancer derived EBC-1 cells. Cytostatic activity was measured by inhibition of (3)H-thymidine uptake by target cells. The mean value of monocyte-mediated cytostasis in HeLa cells was 46.4±11.8% in 18 healthy donors, 47.7±19.0% in 31 patients with bronchogenic carcinoma, 39.9±21.7% in 19 patients with malignant lymphoma, 46.2±17.7% in 14 patients with sarcoidosis, and 48.6±15.7% in 9 patients with pulmonary tuberculosis. The mean value of monocyte-mediated cytostasis in EBC-1 cells was 87.4±8.5 % in 18 healthy donors, 78.9±16.8% in 39 patients with bronchogenic carcinoma, 82.5±15.1% in 25 patients with malignant lymphoma, 87.0±6.7% in 16 patients with sarcoidosis, and 94.3±8.8% in 8 patients with pulmonary tuberculosis. No significant difference between healthy donors and patients with the above mentioned disorders was observed in the HeLa cell assay. But there were remarkably low activities, two standard deviations below the mean value of healthy donors, in 30% of the patients with bronchogenic carcinoma and 14% of the patients with malignant lymphoma in the EBC-1 cell assay. In lung cancer patients no significant positive correlation was observed between monocyte-mediated cytostatic acitivity and other monocyte functions. The data suggest that the tumor cell killing activity of peripheral monocytes was decreased in patients with malignant neoplasma.
Keywords
肺癌
単球
腫瘍細胞増殖抑制
Published Date
1983-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1193
End Page
1200
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/11-12/95_11-12_1193/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma