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ID 16389
Eprint ID
16389
FullText URL
Thumnail 98_1099.pdf 477 KB
Title Alternative
Experimental study on toxicity of trichlotoethane Part 3. Changes in liver function of mice after exposure to 1, 1, 1-and 1, 1, 2-trichloroethane
Author
Takahara, Kazuo
Abstract
Variations in the levels of ATP and triglyceride (TG) in the liver and TG concentration and GPT activity in the plasma of mice exposed to 1, 1, 1-and 1, 1, 2-trichloroethane (TCE) were studied. The decrease in liver ATP, increase in liver TG, decrease in plasma TG and increase in plasma GPT were greater in mice exposed to 1, 1, 2-TCE than in mice exposed to 1, 1, 1-TCE. It was inferred that the biosynthesis of serum lipoprotein in the liver was inhibited, thus causing fatty liver. The increased level in plasma GPT is considered to be a sensitive and early indication of liver disturbance caused by TCE. The decrease in liver ATP, and the increase in liver TG in the mice were in the desending order of carbon tetrachloride, 1, 1, 2, 2-tetrachloroethane, 1, 1, 2-TCE, tetrachloroethylene, trichloroethylene, 1, 1, 1, 2-tetrachloroethane, and 1, 1, 1-TCE. The inhibitory effect of 1, 1, 2-TCE on the liver was stroner than that of 1, 1, 1-TCE, suggesting that the effect of 1, 1, 2-TCE is due to production of free radicals.
Keywords
1,1,1-トリクロロエタン
1,1,2-トリクロロエタン
四塩化炭素
肝ATP
トリグリセライド
Published Date
1986-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1099
End Page
1109
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/98/11-12/98_11-12_1099/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
File Version
publisher
Refereed
True
Eprints Journal Name
joma