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ID 16320
Eprint ID
16320
FullText URL
Thumnail 95_517.pdf 820 KB
Title Alternative
Studies on ifosfamide, a new analogue of cyclophosphamide Part 2, Clinical pharmacology of ifosfamide
Author
Harada, Junichi
Abstract
A new method for quantitative analysis of ifosfamide and its active metabolite, 4-hydroxy-ifosfamide, was applied to determine the optimal mode of administration of ifosfamide. Three each of six patients with extensive bronchogenic carcinoma were given a single 40mg/kg dose of ifosfamide by either a five-minute or 60-minute intravenous infusion, with a second course of treatment 7-21 days later. Using the NaOH method, the pharmacokinetics was investigated to determine which administration schedule, the five-minute or 60-minute infusion, was preferable for the treatment of clinical malignancies. Ifosfamide was quite stable, but 4-hydroxy-ifosfamide was labile in blood samples, though immediate extraction with dichlorethane minimized the lability of 4-hydroxy-ifosfamide. The distribution volume and the transfer constant into 4-hydroxy-ifosfamide of ifosfamide were rather large, while the transfer constant for urinary excretion was rather small after the 60-minute infusion. The amount of unchanged ifosfamide excreted into urine was larger and its excretion more rapid after the five-minute infusion. As for 4-hydroxy-ifosfamide, the elimination constants and the maximum concentration in the blood were similar for both schedules, but the distribution volume was larger after the 60-minute infusion. The urinary excretion of 4-hydroxy-ifosfamide was delayed and the ratio of 4-hydroxy-ifosfamide to unchanged ifosfamide was larger after the 60-minute infusion. These results suggest that the 60-minute intravenous infusion is preferable to the five-minute intravenous infusion.
Keywords
ifosfamide
pharmacology
Published Date
1983-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
517
End Page
533
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/5-6/95_5-6_517/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma