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ID 16301
Eprint ID
16301
FullText URL
Thumnail 95_429.pdf 403 KB
Title Alternative
Studies on antibody-anticancer drug conjugates Part 2. In vivo study of the antibody-Neocarzinostatin conjugate (NCS-immune IgG)
Author
Sato, Yuji
Abstract
The in vivo antitumor activity of NCS-immune IgG (NCS conjugated with rabbit IgG antibody against the human leukemia cell line NALL-1) was evaluated in immunosuppressed newborn Syrian hamsters implanted with a transplantable human leukemia cell line (BALL-1). After i.p. injection of the conjugate, hamsters preinoculated i.p. with BALL-1 cells survived longer than hamsters treated with control solutions (p<0.01). The control solutions included NCS, immune IgG, a mixture of NCS and immune IgG, NCS-normal IgG conjugate and physiological saline. Growth retardation was not observed in NCS-immune IgG treated hamsters. The growth of s.c. implanted BALL-1 tumors was inhibited by i.p. administrations of NCS-immune IgG, however, the degree of inhibition was not significantly different from that obtained by NCS alone, a mixture of NCS and immune IgG or NCS-normal IgG conjugate. These results indicate that NCS-immune IgG was effective against i.p. implanted BALL-1 tumors, but was no so effective against s.c. implanted tumors.
Keywords
Antibody-NCS conjugate
In vivo antitumor activity
Transplantable human leukemia cells
Published Date
1983-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
429
End Page
436
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/5-6/95_5-6_429/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma