このエントリーをはてなブックマークに追加
ID 16275
Eprint ID
16275
FullText URL
Thumnail 95_233.pdf 857 KB
Title Alternative
Function of peripheral blood lymphocytes in patients with systemic lupus erythematosus. Part 1. Characteristics of spontaneously proliferating cells
Author
Morimasa, Kimiaki
Abstract
Increased 3H-Thymidine(3H-TdR) uptake was noticed when peripheral blood mononuclear cells (MNC) from systemic lupus erythematosus(SLE) patients were cultured without any mitogenic stimulation. The peak of 3H-TdR uptake was found immediately after transfering the cells to in vitro culture. DNA synthesizing cells were observed directly by means of autoradiography by pulsing with 3H-TdR for 4 hours. Therefore, it was presumed that there were some MNC in the peripheral blood from SLE patients which were already triggered to proliferate in vivo. These spontaneously proliferating MNC were found to fractionate into a nonadherent, non-E-rosette forming and surface immunoglobulin negative cell population, the so called null cell population. These results suggest that there were activated MNC in the peripheral blood from patients with SLE which fractionated into a null cell population.
Keywords
systemic lupus erythematosus
peripheral blood lymphocytes
spontaneously proliferating cells
null cell fraction
Published Date
1983-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
233
End Page
242
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/3-4/95_3-4_233/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma