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ID 16236
Eprint ID
16236
FullText URL
Thumnail 96_149.pdf 942 KB
Title Alternative
Experimental study on pathogenesis and treatment of cerebral vasospasm. Part 1. Effects of thromboxane A(2) synthetase inhibitor (OKY-046) on experimental cerebral vasospasm.
Author
Motoki, Mototsugu
Abstract
The effects of a thromboxane A(2) synthetase inhibitor (OKY-046: sodium (E)-3-[4-(1-imidazolylmethyl)]-2-propenoate) on the diameter of normal and constricted basilar arteries and on the regional cerebral blood flow (r-CBF) in the brain stem after experimental subarachnoid hemorrhage (SAH) were investigated in 27cats. The basilar artery was exposed transclivally, and the change in its diameter was studied by serial photographs. Both normal and constricted basilar arteries showed only slight dilatation after an intravenous injection of OKY-046 (30mg/kg, 60mg/kg). Mean arterial blood pressure (MABP) decreased dose dependently with the administration of OKY-046. Exprimental SAH was produced by an intracisternal injection of 3ml of fresh autologous arterial blood. Three days later, the basilar artery was exposed transclivally, and an advanced prolonged vasospasm was produced by topical application of a blood-CSF mixture incubatesd at 37℃ for 3days. The change in r-CBF in the brain stem was measured continuously by the heat clearance method before, during and after intravenous administration of OKY-046 (30mg/kg, 60mg/kg). The changes of r-CBF in cats with experimental SAH (n=9) were divided into three types: no change in r-CBF (n=3), a transient decrease in r-CBF related to the decrease in MABP (n=1) and an increase in r-CBF in spite of systemic lypotension (n=5). In 3 control cats, r-CBF decreased in relation to systemic hypotension. These results indicate that thromboxane A(2) is not the major factor of cerebral vasospasm. However, OKY-046 which has been known to inhibit platelet aggregation and to prevent vascular constriction, might be useful in the prophylaxis and treatment of ischemic symptoms in patients with cerebral vasospasm.
Keywords
cerebral vasaspasm
prostaglandin
prostacyclin
thromboxane A(2)
OKY-046
Published Date
1984-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
149
End Page
160
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/1-2/96_1-2_149/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma