このエントリーをはてなブックマークに追加
ID 16209
Eprint ID
16209
FullText URL
Thumnail 97_815.pdf 402 KB
Title Alternative
Changes in substances affecting the central nervous systemin stored blood products. I. Ammonia accumulation in platelet concentrates during storage
Author
Ishii, Akio
Abstract
To study how to control the ammonia level in platelet concentrates during storage, the effects of storage conditions on ammonia accumulation in the product were examined The ammonia level increased significantly with increasing storage temperature from 4℃ to 37℃ and reached approximately 500μmol/l after 72 hours of storage at 22℃. There was a negative relationship between the ammonia level and pH value of the product. The ammonia accumulation due to a fall in pH was depressed by applying a gentle flat-bed mode of agitation during storage. More vigorous agitation, such as elliptical agitation, resulted in higher ammonia accumulation. Analysis of changes in amino acids of the product showed that ammonia was mainly derived from non-enzymatic hydrolysis of glutamine in plasma. Glutamic acid had a preventing effect on the ammonia accumulation. The effect was dose-dependent and required approximately 50mg/dl final concentration to reduce the ammonia level to about half of the normal value. I consider the addition of glutamic acid to the blood preservative to be useful in reducing transfusion reactions due to ammonia.
Keywords
ammonia
glutamine
glutamic acid
platelets
blood preservation
Published Date
1985-10-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
815
End Page
822
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/9-10/97_9-10_815/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma