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ID 16208
Eprint ID
16208
FullText URL
Thumnail 96_27.pdf 1.97 MB
Title Alternative
Anti-inflammatory effect of Prozime-10 (P-10), a proteolytic enzyme I. Anti-inflammatory effect of P-10 on experimental gingivitis
Author
Maki, Kazuo
Abstract
Beagle dogs were anesthetized with pentobarbital-Na, and waxed silk was tightened around the under cut area of the dental necks of both postmolar teeth in the upper jaw. One week later, remarkable signs of gingivitis became apparent, and gingivitis was confirmed histologically. Prozime-10 (P-10, a proteolytic enzyme) and indomethacin were givin either orally in enteric-coated capsules or parenterally (intravenously or subcutaneously) for 7consecutive days. The thickness of gingiva and the volume of exudate in the gingival poket were measured before the operation, 7days after silk ligation and after the completion of the drug administration. The effect of test drugs was evaluated in relation to these changes. Oral administration of 12.5mg/kg P-10 was quite effective in alleviating the inflammatory signs. Indomethacin (5mg/kg, p.o.) was slightly less effective, but significantly effective. In all cases of indomethacin administration, mucous diarrhoea was observed, and in some cases a visible amout of blood was mixed in the stool. No such sign was noted with P-10. The formation of granular tissue in the lamina propria of mucosa facing the waxed silk was noted characteristically in histological examinations of swollen gingiva. However, neither granular tissues nor any signs of inflammation were observed after P-10 administration.
Keywords
歯肉炎
蛋白分解酵素
抗炎症効果
P-10
Published Date
1984-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume96
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
27
End Page
34
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/96/1-2/96_1-2_27/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma