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ID 16202
Eprint ID
16202
FullText URL
Thumnail 97_761.pdf 3.28 MB
Title Alternative
Identification of Lymphocyte Subsets in Lung Cancer Tissue Using Monoclonal Antibodies
Author
Watanabe, Tetsuya
Abstract
Subsets of the infiltrating lymphocytes in lung cancer tissues of 64 patients were identified by immunohistochemical staining (ABC method) using monoclonal antibodies (Leu 2a, Leu 3a+b, Leu 4, Leu 7 and Leu 14). T cells were predominant in lung cencer tissues, and tended to infiltrate into cancer cell nests and stoma, diffusely and focally. On the contrary, B cells in most cases were observed to infiltrate focally apart from cancer cells. There was a significant reverse correlation between the intensity of the T cell infiltration and the tumor T factors, and also between Th/i cell infiltration and the tumor T factors. Th/i cells were more prominent in lung cancer than Ts/c cells, and Ts/c cells scarcely infiltrated. NK, K cells also infiltrated scarcely and sparsely, and there was no correlation between the intensity of NK, K infiltration and the clinical condition. It was concluded that immunohistochemical examination of infiltrating lymphocyte subsets in lung cancer can reveal direct local immune responses and may be a useful method for making prognoses.
Keywords
モノクローナル抗体
リンパ球サブセット
肺癌
肺癌浸潤リンパ球
免疫組織化学
Published Date
1985-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
761
End Page
775
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/7-8/97_7-8_761/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma