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ID 16190
Eprint ID
16190
FullText URL
Thumnail 97_649.pdf 617 KB
Title Alternative
Studies on combination chemotherapy for malignant lymphomaPart I. Drug screening and combination chemotherapy usinga murine lymphosarcoma, LS-1, as a model of malignant lymphoma in man.
Author
Nishihara, Ryuji
Abstract
A murine lymphosarcoma (LS-1) which originated spontaneously in a DBA/2 mouse, was evaluated as a model of malignant lymphoma for drug screening and combination chemotherapy. Antitumor activity was distinct in the order of L-asparaginase (LASP), mitoxantrone, a new anthraquinone analogue (MIT), ifosfamide (IFO), cyclophosphamide (CPA), adriamycin (ADM), and aclarubicin, a new ADM analogue (ACR), when measured as increased life span of mice intravenously implanted with LS-1 and intraperitoneously treated with antitumor agents at an optimal dose. Methotrexate (MTX), vincristine (VCR), and vindesine (VDS) were marginally active against LS-1. Nitrosourea compounds, such as BCNU and ACNU, and bleomycin were inactive against the tumor. The murine lymphosarcoma, LS-1, appeared to provide a drug activity spectrum closely analogous to malignant lymphoma in man except for LASP. The combination of IFO and MIT was the most effective among six 2-drug combinations. CPA and MIT, IFO and ADM, and CPA and ADM were also effective combination. ACR, however, appeared antagonistic to IFO and CPA, since in combination with these agents, ACR did not prolong the life-span at any dose, as compared to the optimal dose of IFO or CPA alone. The murine experimental system using LS-1 should be usefull as a chemotherapy model of malignant lymphoma in man.
Keywords
マウス悪性リンパ腫
化学療法
多剤併用療法
Published Date
1985-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
649
End Page
660
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/7-8/97_7-8_649/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma