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ID 16176
Eprint ID
16176
FullText URL
Thumnail 98_255.pdf 468 KB
Title Alternative
Induction chemotherapy for acute leukemia Part 2. A comparative trial of a combination of daunorubicin and cytosine arabinoside and a combination of aclarubicin and cytosine arabinoside in acute non-lymphocytic leukemia
Author
Hara, Masamichi
Abstract
A comparative trial of a combination of daunorubicin (DNR) and cytosine arabinoside (ara-C) (Regimen A) and a combination of aclarubicin (ACR) and ara-C (Regimen B) was performed. Sixteen patients with acute non-lymphocytic leukemia, previously untreated, included in this study. Five of 8 patients, 62.5%, obtained a complete remission (CR) with both Regimen A and B. The days until CR varied from 37 to 46 in Regimen A and from 22 to 56 in Regimen B. The total doses of DNR and ara-C in Regimen A were from 100 to 240mg and from 640 to 1,120mg, respectively. Those of ACR and ara-C in Regimen B were from 180 to 300mg and from 660 to 1,000mg, respectively. In a comparative study of hematological changes, toxic effects on peripheral white blood cells, platelets and nucleated cells in bone marrow tended to appear later in Regimen B than in Regimen A. Side effects on the digestive system such as nausea and vomiting and vascular pain were more frequently recognized in patients treated with Regimen B, although they were managed by symptomatic treatment. The present comparative study indicated that a new antileukemic anthracycline, ACR, has the same therapeutic activity against ANLL as DNR in combination with ara-C.
Keywords
急性白血病寛解導入療法
aclarubicin
daunorubicin
cytosine arabinoside
Published Date
1986-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
255
End Page
264
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.https://www.jstage.jst.go.jp/article/joma1947/98/3-4/98_3-4_255/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma