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ID 16137
Eprint ID
16137
FullText URL
Thumnail 98_21.pdf 3.76 MB
Title Alternative
The role of the reticular formation of the medulla oblongata in acute brain swelling
Author
Nishiura, Tsukasa
Abstract
The purpose of the present study is to clarify the effect of stimulation of the reticular formation of the medulla oblongata (MORF) on cerebrovascular tone. Using 32 cats, blood pressure (BP), intracranial pressure (ICP) and cerebral blood volume (CBV) were continuously measured. The animals were divided into 4 groups: G(1), normal ICP; G(2), increased ICP due to subarachnoid hemorrhage; G(3), superior cervical ganglionectomy, and G(4), spinal cord transection at C(2). In all animals, the MORF was stimulated after the dorsomedial nucleus of the hypothalamus and the reticular formation of the midbrain were destroyed. The BP was also increased with an intravenous administration of angiotensin II. The vasomotor index (VI), defined by ΔICP/ΔBP, was calculated and compared between the two situations, i.e., MORF stimulation and angiotensin II administration. BP, ICP and CBV increased simultaneously immediately after MORF stimulation. In G(1), G(2) and G(3), the VI with MORF stimulation was significantly higher than that with angiotensin II. The increase in ICP with MORF stimulation was also observed in G(4), although the BP showed no consistent changes in this group.
Keywords
acute brain swelling
cerebral blood volume
cerebrovascular tonus
intracranial pressure
medulla oblongata
Published Date
1986-02-28
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
21
End Page
40
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/98/1-2/98_1-2_21/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma