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ID 16111
Eprint ID
16111
FullText URL
99_1651.pdf 299 KB
Title Alternative
Fate of aromatic solvents in animals. IV. Distribution of toluene in mouse organ and the exhaled air of mice intraperitoneally injected with (14)C-toluene.
Author
Kamiya, Jiroh
Abstract
Mice were injected with (14)C-toluene, and the radioactivity in the blood, exhaled air and organs was determinated liquid scintillation counter. The concentration of toluene in the blood attained a maximum 45 min. after the injection and decreased with a half life of 45 min. The amount of toluene in the exhaled air also attained a maximum 45 min. after the injection and decreased with a half life of 55 min. The exhalation curve of toluene paralleled the concentration curve of toluene in the blood. The ratio of the toluene concentration in red cells to that in plasma was 1:2.24. The concentration of toluene in the organs 180 min after the injection was in the decreasing order of adipose tissue > Kidney > liver > blood > brain. The fraction of the blood containing metabolite was applied to a thin layer plate and developed with toluene:acetic acid:water = 150:50:2.5. The radioactivity of benzoic and hippuric acids on the thin layer chromatogram of blood obtained 480 minutes after the injection was 83% and 17% of the total, respectively.
Keywords
(14)C・トルエン
血中及び臓器中トルエン代謝産物
Published Date
1987-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1651
End Page
1657
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/11-12/99_11-12_1651/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma