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ID 16062
Eprint ID
16062
FullText URL
99_1573.pdf 4.91 MB
Title Alternative
Experimental and electron microscopic study of atrial specific granules
Author
Tobita, Ryouichi
Abstract
The sodium and water balance of rats was varied, and changes in the number and distribution of specific atrial granules (ASG) were observed electron microscopically. The number of ASG in atrial muscle cells increased in rats without salt intake for 7-8 days. On the contrary, the number of ASG began to decrease 10 days after rats were given 2-2.5% sodium chloride solution ad libitum instead of water. After 30 days, the number of ASG decreased markedly in the central sarcoplasmic core, in the sarcoplasmic layer and under the cell membrane. Most atrial muscle cells in rats 6 days after hypophysectomy contained less ASG than those of control rats, and 30 days after the hypophysectomy, only a small number of ASG were observed in the central sarcoplasmic core, in the sarcoplasmic layer and under the cell mumbrane. The number of ASG increased the first 5 days after adrenalectomy, but did not change after 7 days. The number of ASG increased a little 4 weeks after birth in spontaneous hypertensive rats (SHR). ASG increased up to 20 weeks after birth of SHR, concomitantly with an increase in the blood pressure. To study the mode of secretion of ASG in detail, Ca-ionophore A23187 was used. In ionophore-treated cells, exocytotic figures were clearly demonstrated.
Keywords
心房筋特殊顆粒
ナトリウム・水分代謝
下垂体・副腎摘出
高血圧自然発症ラット
分泌形態
Published Date
1987-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1573
End Page
1587
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/11-12/99_11-12_1573/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma