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ID 16046
Eprint ID
16046
FullText URL
99_1449.pdf 845 KB
Title Alternative
Studies on monocytes in acute leukemia II. Monocyte chemiluminescence
Author
Ohmoto, Eijiro
Abstract
Levels of chemiluminescence (ChL) were measured in peripheral monocytes obtained from patients with acute leukemia. Items examined were base line (BL), peak level (PL), peak time (PT) and BL/PL ratio. Levels of monocyte ChL examined during different states of acute leukemia [before chemotherapy, state of complete remission (CR) and state of relapse] showed no significant differences as compared to those in healthy controls. However, prolongation of PT in untreated cases, elevation of BL and low BL/PL ratio in cases of CR and elevation of PL in relapsed cases tended to be observed. Four of 5 acute leukemia patients with CR, in which monocyte ChL was measured sequentially, showed an elevation of BL and PL before and/or during the early stage of relapse. Moderate inverse relations were observed between the percentage of leukemic cells in the marrow and monocyte BL and PL, respectively, and between the absolute counts of monocytes in the blood and monocyte BL and PL, respectively. These results suggest that there are two dynamic phases of monocyte ChL in acute leukemia; namely, BL and PL are rather high when the volume of leukemic cells is small, and BL and PL decrease as leukemic cells enlarge. The sequential measurement of monocyte ChL in the state of CR may aid in the early recognition of relapse.
Keywords
acute leukemia
monocyte
monocyte chemiluminescence
Published Date
1987-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1449
End Page
1460
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/11-12/99_11-12_1449/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma