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ID 16011
Eprint ID
16011
FullText URL
Thumnail 99_1179.pdf 509 KB
Title Alternative
Studies on multidisciplinary treatment of small cell lung cancer Part II. A randomized trial of prophylactic cranial irradiation
Author
Kawahara, Shin
Abstract
In order to assess the usefulness of prophylactic cranial irradiation (PCI) in the treatment of small cell lung cancer, 43 complete responders to chemotherapy were randomized either to receive PCI or to have observation only between April 1981 and September 1986. Twenty-one patients were given 40 Gy of PCI in 20 fractions over 4 weeks after they had achieved complete response. Of those, 5 patients (24%) developed brain metastases within a median follow-up period 47.5 months (range, 15.5 to 67 months), while 11 of 22 patients (50%) not receiving PCI developed brain metastases within a median follow-up period of 40.5 months (range, 13 to 70 months). Cumulative actual probability of a brain metastasis was 5% at 12 months and 25% at 24 months for those receiving PCI, while it was 38% at 12 months and 53% at 24 months for those not receiving PCI. Thus, the probability of a brain metastasis was significantly lower in the PCI group than in the control group. The median survival time was 21 months for the PCI group and 14.7 months for the control group. The 2-year survival rate was also higher in the PCI group (35% versus 14%). However, the differences were not statistically significant due to the small number of patients. These interim results suggest the possibility of reducing brain metastases and prolonging survival by PCI in complete responders to chemotherapy.
Keywords
肺小細胞癌
完全寛解
脳転移
予防的脳照射
Published Date
1987-10-31
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue9-10
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1179
End Page
1188
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1179/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma