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ID 15985
Eprint ID
15985
FullText URL
Thumnail 99_1003.pdf 486 KB
Title Alternative
Effect of α-hANP on coronary circulation and myocardial contractility
Author
Shimizu, Akinori
Abstract
The effect of synthetic human atrial 28-amino acid peptide (α-human atrial natriuretic polypeptide, α-hANP) on coronary circulation and cardiac functions were examined in openchest dogs. Continuous infusion of α-hANP into the left anterior descending coronary artery (LAD) increased blood flow of the LAD in a dosedependent manner. Linear regression analysis revealed the relationship as logit (changes in mean coronary conductance (MCC)=1.45×log (coronary plasma concentration of α-hANP) + 7.51, (r = 0.87, n = 29). REC50 of α-hANP was 5.1×10(-6)M, where REC50 was the concentration to increase MCC to a half maximum MCC during reactive hyperemia after a 30-second coronary occlusion. A force straingauge arch was inserteed directly onto the myocardium supplied by the LAD. Indices of myocardial contractility measured, myocardial force (F), max dF/dt and LVmax dp/dt, were not altered by either bolus intravenous injection or continuous intracoronary infusion of α-hANP. These results suggest that α-hANP increased coronary conductance, but did not change myocardial contractility.
Keywords
α-hANP
冠血流量
局所心筋張力
麻酔開胸犬
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1003
End Page
1012
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_1003/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma