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ID 15978
Eprint ID
15978
FullText URL
Thumnail 99_943.pdf 603 KB
Title Alternative
Studies on the Pathogenesis of Duodenal Ulcer from the Viewpoint of the Gastro-Pancreatic Secretory Relationship. 1. Gastric and Pure Pancreatic Juice Secretion in Response to Exogenous Hormone Stimulation.
Author
Hanafusa, Eiji
Abstract
Comparative studies on gastric secretory function and exocrine pancreatic secretory function were made in 9 normal controls, 6 patients with gastric ulcer and 10 patients with duodenal ulcer by analysis of gastric juice and pure pancreatic juice (PPJ). Gastric juice was obtained through a Rehfuss tube at 10-minute intervals for 60 minutes before and after AOC-tetra-gastrin stimulation (4 μg/kg). PPJ was obtained by endoscopic retrograde catheterization of the papilla at one-minute intervals for 20 minutes after a bolus intravenous injection of secretin (Eisai, 1 U/kg) and for 10 minutes after an injection of CCK-PZ (Boots, 1 U/kg). Patients with duodenal ulcer had significantly high basal acid output (BAO) and maximal acid output (MAO), a significantly high bicarbonate concentration in the initial fraction of PPJ, and significantly high bicarbonate output during the secretin phase. A significant correlation was noted between the bicarbonate concentration in the initial fraction of the PPJ and the BAO and MAO, and also between the bicarbonate output and the BAO and MAO. These results indicate that bicarbonate secretion of the pancreas in response to secretin is proportionally raised in patients with duodenal ulcer to neutralize the raised gastric acid secretion. These findings were discussed in relation to the pathogenesis of duodenal ulcer.
Keywords
胃膵分泌相関
十二指腸潰瘍
純粋膵液
胃液分泌
膵外分泌
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
943
End Page
954
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_943/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma