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ID 15971
Eprint ID
15971
FullText URL
Thumnail 99_891.pdf 1.06 MB
Title Alternative
Mechanism of the dissolution of enflurane and isoflurane into human, dog and bovine blood
Author
Tada, Keiichi
Abstract
This study was performed to elucidate the difference in the mechanism of the dissolution of enflurane and isoflurane into human, dog and bovine blood in terms of changes in the hematocrit using the highly accurate analytical method of direct gas chromatography. With enflurane, as the hematocrit increased, the blood-gas partition coefficient for human and bovine blood decreased linearly (P < 0.001), and that for dog blood increased linearly (P < 0.001). With isoflurane, as the hematocrit increased, the blood-gas partition coefficient for the blood of all three animals decreased linearly (P < 0.001). Enflurane has a stroger affinity for red cells than for plasma in dog blood, as indicated by positive linearlity, while the opposite is true in human and bovine blood, as indicated by negative linearlity. Isoflurane has a stronger affinity for plasma than for red cells as indicated by negative linearlity in human, dog and bovine blood. The characteristic value of the red cell/plasma partition coefficient was 2.92 for enflurane in dog blood, and 0.09 for isoflurane in human blood.
Keywords
血液/ガス分配係数
血球/血漿分配係数
enflurane
isoflurane
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
891
End Page
901
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_891/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma