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ID 15958
Eprint ID
15958
FullText URL
Thumnail 99_787.pdf 940 KB
Title Alternative
Guanidino compounds in iron-induced epileptogenic foci of rats
Author
Fukushima, Masato
Abstract
Changes in the levels of guanidino compounds in the cortex, hippocampus, striatum, hypothalamus, midbrain, pons and medulla oblongata and cerebellum were analyzed by high performance liquid chromatography after an injection of ferric chloride into the sensory motor cortex of SD rats. Levels of guanidinoacetic acid (GAA) and methylguanidine (MG) changed greatly 15 and 30 min after the injection, but recovered to normal levels 24 to 48 hours after the injection. GAA and MG increased two or three times the normal level 2 months after the injection, at which time iron-induced epileptogenic foci were formed. Levels of other guanidino compounds, i.e., N-acetylarginine, guanidinoacetic acid, arginine (Arg), homoarginine and creatinine (CRN) also changed, though the extent of the changes was not as marked as with GAA and MG. Rapidly increased generation of hydroxyl radical and peroxide intermediate radical(s) was observed by electron spin resonance analysis after addition of ferric chloride and hydrogen peroxide to rat brain homogenate. Levels of MG and GAA also increased. A significant relationship between the generation of hydroxyl radical and the formation of MG was recognized. The formation of MG in the system was dependent on the concentration of CRN but independent of the concentration of Arg and GAA. These results suggest that MG formed from CRN may act on neurones after iron injection into the rat brain, thus forming epileptogenic feci.
Keywords
鉄塩誘導てんかん原性焦点
グアニジノ化合物
ラット
ラジカル反応
メチルグアニジン
Published Date
1987-08-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume99
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
787
End Page
806
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/99/7-8/99_7-8_787/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma