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ID 15950
Eprint ID
15950
FullText URL
Thumnail 100_547.pdf 512 KB
Title Alternative
Bactericidal activity of polymorphonuclear leukocytes against pathogenic bacteria and the function of B lymphocytes in critiacally ill patients
Author
Akao, Masaki
Abstract
I studied host resistance to infection in critically ill patients with nosocomial pneumonia due to gram-negative bacilli. The bactericidal activity of polymorphonuclear leukocytes (PMNs) against pathogenic bacteria was estimated by zymosan-induced and bacteria-induced chemiluminescence (CL). The function of B lymphocytes was examined by measurement of lymphocyte numbers, subpopulations, subsets, and plasma immunoglobulins. The zymosaninduced CL did not correlate significantly with the bacteria-induced CL. This finding indicates that zymosan cannot be used for the estimation of bactericidal activity of PMN against pathogenic bacteria in critically ill patients. Lymphocyte numbers were very low, and the parcentage of suppressor T lymhocytes was low, and consequently the ratio of helper to suppressor T lymphocytes was somewhat high. There was a significant negative correlation between the plasma level of IgG and the percentage of B lymphocytes (p<0.05). The bactericidal activity of PMNs and the function of B lymphocytes tended to be suppressed as the plasma level of IgG increased. From these results, I conclude that: 1. There is negative feedback between IgG and B lymphocytes. 2. Host resistance to infection is suppressed in critically ill patients, if IgG is elevated.
Keywords
重症患者
ケミルミネッサンス
好中球殺菌能
B細胞
IgG
Published Date
1988
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume100
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
547
End Page
554
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/100/5-6/100_5-6_547/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma