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ID 15123
Eprint ID
15123
FullText URL
Title Alternative
T cell subpopulation and asthma classification
Author
Mifune, Takashi
Yokota, Satoshi
Hosaki, Yasuhiro
Kajimoto, Kazuhiro
Tanizaki, Yoshiro
Abstract
気管支喘息症例の臨床病型に対するTリンパ球の役割を明らかにするために,気管支肺胞洗浄液中のCD3,CD4,CD8陽性細胞の比率を検討した。1.Ia気管支攣縮型におけるCD3陽性細胞は75.6±6.52%,Ib:過分泌型では75.4±16.5%,Ⅱ:細気管支閉塞型では61.0±12.5%であり,いずれの病型においても有意な差は認められなかった。2.CD4陽性細胞についてはIa型47.4±6.11%,Ib型39.5±8.70%,Ⅱ型46.3±6.91%,CD8陽性細胞についてはIa型28.3±8.77%,Ib型35.5±12.3%,Ⅱ型29.4±11.5%と過分泌型 で他の2病型とは違う傾向を示したが,有意ではなかった。3.活性化を示すHLA-DR陽性細胞はCD4,CD8陽性細胞とも気管支攣縮型で高い傾向が認 められたが有意ではなかった。以上,今回の検討では各臨床病型間でTリンパ球の関与に明らかな差は見られなかったが,気管支攣縮型に対する活性型Tリンパ球より強い関与の可能性が示唆された。
Abstract Alternative
To clarify the role of T lymphocyte to patho physio logical changls in He aiways, the relationship between T cell subpopulation in BALF and each clinical asthma type were investigated. The proportion of BALF CD3 +T cells in patients with Ia : simple bronchoconstriction type was 75.6±6.52%, 75.4±16.5% in those with Ib : hypersecretion type and 61.0±12.5% in those with Ⅱ : bronchiolar obstruction type. No siginificant differences were observed between 3 asthma types. The proportion of BALF CD4 +T cells and CD8 +T cells revealed different tendency in patients with type Ib, compaired to patients with type Ia or type Ⅱ, but this was not significant. A higher proportion of CD4 + and CD8 +T cells in BALF expressing the T cell activation marker HLA-DR was observed in patients with type Ia. compared to those with other clinial asthma types. However, these were not significant.
Keywords
気管支喘息臨床病型 (clinical type of beonchial asthma)
Tリンパ球 (T-lymphocyte)
CD4陽性リンパ球 (CD4+lymphocyte)
CD8陽性リンパ球 (CD8+lymphocyte)
活性化リンパ球 (activated lymphocyte)
Published Date
1995-09
Publication Title
岡大三朝分院研究報告
Publication Title Alternative
Annual Reports of Misasa Medical Branch, Okayama University Medical School
Volume
volume66
Publisher
岡山大学医学部附属病院三朝分院
Publisher Alternative
Misasa Medical Branch, Okayama University Medical School
Start Page
44
End Page
48
ISSN
0918-7839
NCID
AN10430852
Content Type
Departmental Bulletin Paper
language
日本語
OAI-PMH Set
岡山大学
File Version
publisher
Refereed
False
Sort Key
7
Eprints Journal Name
mmc