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ID 15109
Eprint ID
15109
FullText URL
Title Alternative
A case of multiple pancreatic cysts with K-ras point mutation in pure pancreatic juice
Author
Yamamoto, Ryoichi
Ochi, Koji
Matsumura, Naoki
Tanaka, Juntaro
Kato, Tadahiro
Chowdhury Riaz
Harada, Hideo
Hasuoka, Hideaki
Yokota, Satoshi
Tanizaki, Yoshiro
Abstract
膵癌の早期診断を行うために,最近の進歩の著しい遺伝子診断を用いて,膵液中のK-ras遺伝子の点突然変異の検討がなされている。われわれは膵液の細胞診は陰性であるが,K-ras遺伝子の点突然変異を認め,膵全体に多発する膵嚢胞の1例を経験した。本例は悪性であるとの確診が得られないことや切除するとなれば膵全摘となることなどのために,経過観察を行っているが,18カ月後の現在,嚢胞の増大など認めていない。膵癌の遺伝子診断の文献的考察を含め,報告する。
Abstract Alternative
Pancreatic cancer is the one of the leading causes of death among cancer deaths and the early diagnosis is one of the main topics of pancreatic research. Mutation of K-ras oncogene at codon 12 has been reported in pancreatic adenoma, hyperplasia of the pancreatic duct, and also in pancreatic cancer, Recently, detection of K-ras point mutation in pure pancreatic juice is underinvestigation as a potential tool of early diagnosis of pancreatic cancer by setting a certain cut-off value. We recently experienced a case of multiple pancreatic cysts without any malignant cells in pancreatic juice, but with a positve point mutation of K-ras oncogene. Operation was deferred after obtaining informed consent from the family, because the lesions were so multiple and extensive as to require total pancreatectomy. Eighteen months follow-up studies did not reveal any deterioration in imaging tests as well as clinical picture.
Keywords
膵嚢胞 (pancreatic cyst)
膵液 (pancreatic juice)
K-ras遺伝子 (K-ras oncogene)
点突然変異 (point mutation)
細胞診 (cytology)
Published Date
1996-11
Publication Title
岡大三朝分院研究報告
Publication Title Alternative
Annual Reports of Misasa Medical Branch, Okayama University Medical School
Volume
volume67
Publisher
岡山大学医学部附属病院三朝分院
Publisher Alternative
Misasa Medical Branch, Okayama University Medical School
Start Page
121
End Page
125
ISSN
0918-7839
NCID
AN10430852
Content Type
Departmental Bulletin Paper
language
日本語
OAI-PMH Set
岡山大学
File Version
publisher
Refereed
False
Sort Key
19
Eprints Journal Name
mmc