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ID 14500
Eprint ID
14500
FullText URL
Thumnail 103_209.pdf 653 KB
Title Alternative
Toxicokinetic study of several organic solvents
Author
Yunoki, Emiko
Abstract
Toxicokinetic study on organic solvents was carried out using the data obtained by controlled exposure experiments. Organic solvents used in the present study were chlorobenzene, toluene, m-xylene and trichloroethylene. Molar ratio urinary metabolites to organic solvents inhaled was different among solvents and was between 7.7% and 70.8%. The relationship between the amount of exposed toluene and the amount of hippuric acid was linear. However, for m-xylene, the amount of its urinary metabolites was not so much in comparison with the amount of exposed solvent at higher level exposure of 1400ppm × hour. Simulation of the excretion curves of urinary metabolites after cessation of exposure to organic solvents was fit for the two-compartment exponential model. Using the parameters of one compartment model of the single exposure to these organic solvents, the estimated metabolite level curve obtained by repeated exposures could be drawn, and relationship between biological half lives and critical sampling time was discussed. In respect to the urinary metabolites, the excretion rate of metabolites in the urine collected at the end of exposure depended on the period of time from the last urination to the end of exposure.
Keywords
有機溶剤
尿中代謝産物
生物学的モニタリング
生物学的半減期
反復暴露
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
209
End Page
221
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_209/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
References
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language
日本語
Copyright Holders
岡山医学会
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publisher
Refereed
True
Eprints Journal Name
joma