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ID 14460
Eprint ID
14460
FullText URL
Thumnail 103_95.pdf 450 KB
Title Alternative
The effects of acute respiratory pH changes on the activated coagulation time
Author
Seto, Kozo
Abstract
The effects of acute respiratory acidosis and alkalosis on the activated coagulation time (ACT) of both pre-heparinized and post-heparinized blood samples were studied in adult mongrel dogs. The ACT of pre-heparinized samples, compared with the ACT at a normal pH, was significantly shortened with the progression of acidosis. The correlation coefficient between the ACT of pre-heparinized samples and the pH values during acidosis was 0.55 (p<0.01). During alkalosis, however, the ACT of pre-heparinized samples showed no significant changes. On the other hand, the ACT of post-heparinized samples, compared with the ACT at a normal pH, showed significant prolongation with the progression of both acidosis and aklalosis. The correlation coefficient between the ACT of post-heparinized samples and the pH values was -0.74 (p<0.001) during acidosis, and was 0.55 (p<0.01) during alkalosis. These results indicate that, although the mechanism of the alteration of ATC due to the acute respiratory pH changes seemed to be multifactorial, the ACT in the presence of pH abnormality does not reflect the actual blood concentration of heparin correctly.
Keywords
へパリン
賦活凝固時間
呼吸性アシドーシス
呼吸性アルカローシス
Note
原著
Published Date
1991
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
95
End Page
103
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_95/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma