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ID 14239
Eprint ID
14239
FullText URL
Thumnail 104_145.pdf 301 KB
Title Alternative
Measurement of Danazol and its metabolites by automated direct assay system
Author
Kiyama, Satoshi
Abstract
An automated direct assay system using high performance liquid chromatography was developed for teh measurement of Danazol ; DA and its two metabolites, △(1)-2-hydroxymethylethisterone (△(1)-2-HME), and 2-hydroxymethylethisterone (2-HME), in biologi-cal fluid (human serum and ascites). Serum concentrations of these compounds were measured up to 24 h following a single oral administration of 200mg of DA to 6 females with en-dometriosis. The maximum serum concentration of DA, △(1)-2-HME and 2-HME was 208, 44 and 58ng/ml, respectively. The serum half-life of DA, △(1)-2-HME and 2-HME was 7.9, 4.3 and 4.4 h, respectively. The mean serum concentration of DA and its two metabolites at the the sampling time (2 h after oral administration of 200mg of DA every 4 weeks) hardly changed in the patients administered 400mg/day of DA over a period of 16 weeks. DA and △(1)-2-HME were detectable in ascites 2, 4 and 8 h after oral administration of 200mg of DA, and 2-HME was detectable in ascites at 4 and 8 h. This system could quantify DA and its matabolites easily and simultaneously, and was considered to be valuable in the studies on the relationship between the pharmaco-kinetics and the clinical effects of DA.
Keywords
高速液体クロマトグラフィー
ダナゾール
ダナゾール代謝産物
Published Date
1992
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
145
End Page
150
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
http://www.journalarchive.jst.go.jp/japanese/jnlabstract_ja.php?cdjournal=joma1947&cdvol=104&noissue=1-2&startpage=145
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma