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ID 14222
Eprint ID
14222
FullText URL
Thumnail 103_841.pdf 16.8 MB
Title Alternative
Experimental study on the hepatic effects of sevoflurane anesthesia
Author
Okada, Naoki
Abstract
The hepatic effects of sevoflurane administered under different inspiratory oxygen concentrations were examined. Male rats pretreated with phenobarbital for 5 days and fasted for 24 hours were anesthetized with 2.4% sevoflurane administered under different oxygen concentrations (10%, 14%, 21% or 100%). The rats administered sevoflurane under 21% oxygen were used as the control. The amount of microsomal protein, the content and activity of hepatic microsomal enzymes, and the amount of enzymes released from the liver cells (GPT, OCT) of each group of rats were measured for 7 days after these procedures. The content of cytochrome P-450 and the activity of aminopyrine demethylation and aniline dehydration were decreased significantly to about 58%, 43% and 40% that of the control, respectively. Furthermore the plasma level of GPT and OCT was elevated to 1,107±620 IU/L and 422±270 IU/L respectively soon after sevoflurane anesthesia only in the group of rats administered sevoflurane under a 10% oxygen concentration. In this study, severe damage to the liver of the rats was observed after sevoflurane anesthesia under 10% oxygen following enzyme induction and fasting.
Keywords
セボフルレン麻酔
吸入酸素濃度
チトクローム P-450
肝障害
Note
原著
Published Date
1991-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume103
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
841
End Page
857
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/103/7-8/103_7-8_841/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma