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ID 14193
Eprint ID
14193
FullText URL
Thumnail 104_821.pdf 1.28 MB
Title Alternative
Brain tissue leukotrienes in cerebral ischemia and effect of inhibitor of SRS-A release on postischemic cerebral edema
Author
Takasugi, Noriko
Abstract
Arachidonic acid metabolites are postulated to play a role in the pathogenesis of cerebral ischemia. To examine the development of lipoxygenase metabolites of arachidonic acid in cerebral ischemia, we measured the concentration of leukotriene C4 in the gerbil forebrain following ischemia, and pretreated several animals with cyclooxygenase and lipoxygenase inhibitors. The leukotriene C4 concentration was significantly increased 1 hour after transient ischemia and cerebral edema. The incerase in the concentration of leukotriene metabolites was significantly suppressed by preteratment with the lipoxygenase inhibitors except for the cyclooxygenase inhibitor and phospholipase A2 inhibitor. Intracerebral cerebral injection of leukotriene C4 produced local intracerebral edema. Cycloxygenase inhibition may result in increased substrate availability for the lipoxygenase system. Studies of such an interaction help elucidate the pharmacological modification of detrimental vascular changes after transient cerebral ischemia.
Keywords
leukotrienes
lipoxygenase
ischemia
gerbil
Note
原著
Published Date
1992-08
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume104
Issue
issue7-8
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
821
End Page
832
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/104/7-8/104_7-8_821/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
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language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma